2vpg: Difference between revisions

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==Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex==
==Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex==
<StructureSection load='2vpg' size='340' side='right' caption='[[2vpg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2vpg' size='340' side='right'caption='[[2vpg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vpg]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VPG FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vpg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DA2:NG,NG-DIMETHYL-L-ARGININE'>DA2</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DA2:NG,NG-DIMETHYL-L-ARGININE'>DA2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vp7|2vp7]], [[2vpb|2vpb]], [[2vpd|2vpd]], [[2vpe|2vpe]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpg OCA], [https://pdbe.org/2vpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpg RCSB], [https://www.ebi.ac.uk/pdbsum/2vpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpg OCA], [http://pdbe.org/2vpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vpg RCSB], [http://www.ebi.ac.uk/pdbsum/2vpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpg ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).<ref>PMID:11955446</ref> 
[https://www.uniprot.org/uniprot/PYGO1_HUMAN PYGO1_HUMAN] Involved in signal transduction through the Wnt pathway.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpg_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpg_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Bienz, M]]
[[Category: Large Structures]]
[[Category: Evans, P]]
[[Category: Bienz M]]
[[Category: Fiedler, M]]
[[Category: Evans P]]
[[Category: Mieszczanek, J]]
[[Category: Fiedler M]]
[[Category: Muller, J]]
[[Category: Mieszczanek J]]
[[Category: Nekrasov, M]]
[[Category: Muller J]]
[[Category: Rybin, V]]
[[Category: Nekrasov M]]
[[Category: Sanchez-Barrena, M J]]
[[Category: Rybin V]]
[[Category: Bcl9 hd1 domain]]
[[Category: Sanchez-Barrena MJ]]
[[Category: Gene regulation]]
[[Category: Histone h3k4me2]]
[[Category: Hpygo1 phd domain]]
[[Category: Metal-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Proto-oncogene]]
[[Category: Signaling protein]]
[[Category: Wnt signaling complex]]
[[Category: Wnt signaling pathway]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/2vpg"