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==The crystal structure of an amidohydrolase from Mycoplasma synoviae==
==The crystal structure of an amidohydrolase from Mycoplasma synoviae==
<StructureSection load='3msr' size='340' side='right' caption='[[3msr]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
<StructureSection load='3msr' size='340' side='right'caption='[[3msr]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3msr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs5 Mycs5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MSR FirstGlance]. <br>
<table><tr><td colspan='2'>[[3msr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasmopsis_synoviae_53 Mycoplasmopsis synoviae 53]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MSR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.162&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HAD, MS53_0025 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=262723 MYCS5])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3msr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msr OCA], [https://pdbe.org/3msr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3msr RCSB], [https://www.ebi.ac.uk/pdbsum/3msr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3msr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3msr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msr OCA], [http://pdbe.org/3msr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3msr RCSB], [http://www.ebi.ac.uk/pdbsum/3msr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3msr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PFLAC_MYCS5 PFLAC_MYCS5] Catalyzes the hydrolysis of D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. Also able to hydrolyze carboxy 1,4-lactones.<ref>PMID:24955762</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/3msr_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/3msr_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3msr ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3msr ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycs5]]
[[Category: Large Structures]]
[[Category: Burley, S K]]
[[Category: Mycoplasmopsis synoviae 53]]
[[Category: Structural genomic]]
[[Category: Burley SK]]
[[Category: Swaminathan, S]]
[[Category: Swaminathan S]]
[[Category: Zhang, Z]]
[[Category: Zhang Z]]
[[Category: Amidohydrolase]]
[[Category: Had]]
[[Category: Hydrolase]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]
[[Category: Sgx]]

Latest revision as of 06:30, 27 November 2024

The crystal structure of an amidohydrolase from Mycoplasma synoviae

3msr, resolution 2.16Å

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