4b1b: Difference between revisions
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==Crystal structure of Plasmodium falciparum oxidised Thioredoxin Reductase at 2.9 angstrom== | ==Crystal structure of Plasmodium falciparum oxidised Thioredoxin Reductase at 2.9 angstrom== | ||
<StructureSection load='4b1b' size='340' side='right' caption='[[4b1b]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4b1b' size='340' side='right'caption='[[4b1b]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b1b]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4b1b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B1B FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1b OCA], [https://pdbe.org/4b1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b1b RCSB], [https://www.ebi.ac.uk/pdbsum/4b1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1b ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TRXR_PLAF7 TRXR_PLAF7] Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins (PubMed:9368022, PubMed:11013257, PubMed:16910770, PubMed:23845423). Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO (PubMed:11013257). Has no catalytic activity towards oxidized glutathione (GSSG) (PubMed:11013257).<ref>PMID:11013257</ref> <ref>PMID:16910770</ref> <ref>PMID:23845423</ref> <ref>PMID:9368022</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Thioredoxin | *[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Plasmodium falciparum]] | ||
[[Category: Angelucci | [[Category: Angelucci F]] | ||
[[Category: Bellelli | [[Category: Bellelli A]] | ||
[[Category: Boumis | [[Category: Boumis G]] | ||
[[Category: Brunori | [[Category: Brunori M]] | ||
[[Category: Dimastrogiovanni | [[Category: Dimastrogiovanni D]] | ||
[[Category: Giardina | [[Category: Giardina G]] | ||
[[Category: Miele | [[Category: Miele AE]] | ||
[[Category: Saccoccia | [[Category: Saccoccia F]] | ||
Latest revision as of 11:41, 20 December 2023
Crystal structure of Plasmodium falciparum oxidised Thioredoxin Reductase at 2.9 angstrom
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