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==Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form==
==Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form==
<StructureSection load='3vdk' size='340' side='right' caption='[[3vdk]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3vdk' size='340' side='right'caption='[[3vdk]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vdk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VDK FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VDK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.847&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vdj|3vdj]], [[3vdl|3vdl]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PFC0210c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdk OCA], [https://pdbe.org/3vdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vdk RCSB], [https://www.ebi.ac.uk/pdbsum/3vdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdk OCA], [http://pdbe.org/3vdk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vdk RCSB], [http://www.ebi.ac.uk/pdbsum/3vdk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSP_PLAF7 CSP_PLAF7] Essential sporozoite protein (PubMed:29554084, PubMed:32150583). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:29554084, PubMed:32150583). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity).[UniProtKB:P23093]<ref>PMID:29554084</ref> <ref>PMID:32150583</ref>  In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.[UniProtKB:P23093]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plaf7]]
[[Category: Large Structures]]
[[Category: Doud, M B]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Koksal, A C]]
[[Category: Doud MB]]
[[Category: Lu, C]]
[[Category: Koksal AC]]
[[Category: Mi, L Z]]
[[Category: Lu C]]
[[Category: Song, G]]
[[Category: Mi LZ]]
[[Category: Springer, T A]]
[[Category: Song G]]
[[Category: Atsr]]
[[Category: Springer TA]]
[[Category: Cell invasion]]
[[Category: Tsr]]
Retrieved from "https://proteopedia.org/3vdk"