4cri: Difference between revisions
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==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide== | ==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide== | ||
<StructureSection load='4cri' size='340' side='right' caption='[[4cri]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='4cri' size='340' side='right'caption='[[4cri]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [https://pdbe.org/4cri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [https://www.ebi.ac.uk/pdbsum/4cri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Arrowsmith | [[Category: Homo sapiens]] | ||
[[Category: Bountra | [[Category: Large Structures]] | ||
[[Category: Carr | [[Category: Arrowsmith CH]] | ||
[[Category: Crawley | [[Category: Bountra C]] | ||
[[Category: Carr S]] | |||
[[Category: Edwards | [[Category: Crawley L]] | ||
[[Category: Fedorov | [[Category: Edwards A]] | ||
[[Category: Gileadi | [[Category: Fedorov O]] | ||
[[Category: Johansson | [[Category: Gileadi C]] | ||
[[Category: Krojer | [[Category: Johansson C]] | ||
[[Category: | [[Category: Krojer T]] | ||
[[Category: | [[Category: La Thangue NB]] | ||
[[Category: Vollmar | [[Category: Oppermann U]] | ||
[[Category: | [[Category: Vollmar M]] | ||
[[Category: Von Delft F]] | |||
Latest revision as of 12:15, 20 December 2023
Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide
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