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==Crystal Structure of Amidotransferase HisH from Vibrio cholerae==
==Crystal Structure of Amidotransferase HisH from Vibrio cholerae==
<StructureSection load='4gud' size='340' side='right' caption='[[4gud]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='4gud' size='340' side='right'caption='[[4gud]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gud]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GUD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.911&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hisH, VC_1136 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gud OCA], [https://pdbe.org/4gud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gud RCSB], [https://www.ebi.ac.uk/pdbsum/4gud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gud ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gud OCA], [http://pdbe.org/4gud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gud RCSB], [http://www.ebi.ac.uk/pdbsum/4gud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gud ProSAT]</span></td></tr>
</table>
</table>
== Function ==
 
[[http://www.uniprot.org/uniprot/HIS5_VIBCH HIS5_VIBCH]] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity).
==See Also==
*[[IGPS 3D structures|IGPS 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibch]]
[[Category: Large Structures]]
[[Category: Anderson, W F]]
[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Kim, Y]]
[[Category: Kim Y]]
[[Category: Maltseva, N]]
[[Category: Maltseva N]]
[[Category: Shatsman, S]]
[[Category: Shatsman S]]
[[Category: Alpha-beta sandwich]]
[[Category: Csgid]]
[[Category: Cytosol]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Transferase]]