2j91: Difference between revisions

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~~[[Image:2j91.gif|left|200px]]<br />~~

~~<applet load="2j91" size="450" color="white" frame="true" align="right" spinBox="true"~~

~~caption="2j91, resolution 1.80Å" />~~

~~'''CRYSTAL STRUCTURE OF HUMAN ADENYLOSUCCINATE LYASE IN COMPLEX WITH AMP'''<br />~~

==~~About this Structure~~==

==Crystal structure of Human Adenylosuccinate Lyase in complex with AMP==

~~2J91~~ is a [~~[http~~://en.wikipedia.org/wiki/~~Single_protein Single protein~~]] ~~structure of sequence~~ from [[http://en.~~wikipedia~~.org/~~wiki~~/~~Homo_sapiens Homo sapiens~~]] ~~with~~ CL, ~~AMP and~~ GOL as [[http://en.~~wikipedia~~.org/~~wiki~~/~~ligands ligands~~]]. ~~This structure superseeds the now removed PDB entry 2J84~~. ~~Active as [~~[~~http~~://en.~~wikipedia~~.org/~~wiki~~/ ]], ~~with EC number~~ [~~[http~~://www.~~brenda-enzymes~~.~~info~~/~~php~~/~~result_flat~~.~~php4?ecno~~=4.3.2.~~2 4~~.3.2.2]]~~. Full crystallographic information is~~ available from [[http://~~ispc~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2J91 OCA~~]].

== Structural highlights ==

<table><tr><td colspan='2'>[[2j91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2j84 2j84]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J91 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j91 OCA], [https://pdbe.org/2j91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j91 RCSB], [https://www.ebi.ac.uk/pdbsum/2j91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j91 ProSAT]</span></td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/PUR8_HUMAN PUR8_HUMAN] Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency) [MIM:[https://omim.org/entry/103050 103050]. ADSL deficiency is an autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present.

== Function ==

[https://www.uniprot.org/uniprot/PUR8_HUMAN PUR8_HUMAN]

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/2j91_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j91 ConSurf].

==See Also==

*[[Adenylosuccinate lyase 3D structures|Adenylosuccinate lyase 3D structures]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: ~~Single protein~~]]

[[Category: Large Structures]]

[[Category: Arrowsmith, C~~.]]~~

[[Category: Arrowsmith C]]

~~[[Category: Berg, S.Van.Den.~~]]

[[Category: Berglund H]]

[[Category: Berglund, H.]]

[[Category: Busam R]]

[[Category: Busam, R.]]

[[Category: Collins R]]

[[Category: Collins, R.]]

[[Category: Edwards A]]

[[Category: Edwards, A.]]

[[Category: Ericsson UB]]

[[Category: Ericsson~~, U.B.~~]]

[[Category: Flodin S]]

[[Category: Flodin, S.]]

[[Category: Flores A]]

[[Category: Flores, A.]]

[[Category: Graslund S]]

[[Category: Graslund, S.]]

[[Category: Hallberg BM]]

[[Category: Hallberg~~, B.M.~~]]

[[Category: Hammarstrom M]]

[[Category: Hammarstrom, M.]]

[[Category: Hogbom M]]

[[Category: Hogbom, M.]]

[[Category: Holmberg Schiavone L]]

[[Category: Johansson, I.]]

[[Category: Johansson I]]

[[Category: Karlberg, T.]]

[[Category: Karlberg T]]

[[Category: Kosinska, U.]]

[[Category: Kosinska U]]

[[Category: Kotenyova, T.]]

[[Category: Kotenyova T]]

[[Category: Magnusdottir, A.]]

[[Category: Magnusdottir A]]

[[Category: Moche, M.]]

[[Category: Moche M]]

[[Category: Nilsson~~, M.E.~~]]

[[Category: Nilsson ME]]

[[Category: Nilsson-Ehle, P.]]

[[Category: Nilsson-Ehle P]]

[[Category: Nordlund, P.]]

[[Category: Nordlund P]]

[[Category: Nyman, T.]]

[[Category: Nyman T]]

[[Category: Ogg, D.]]

[[Category: Ogg D]]

[[Category: Persson, C.]]

[[Category: Persson C]]

[[Category: Sagemark, J~~.]]~~

[[Category: Sagemark J]]

~~[[Category: Schiavone, L.Holmberg.~~]]

[[Category: Stenmark P]]

[[Category: Stenmark, P.]]

[[Category: Sundstrom M]]

[[Category: Sundstrom, M.]]

[[Category: Thorsell AG]]

[[Category: Thorsell~~, A.G.~~]]

[[Category: Uppenberg J]]

[[Category: Uppenberg, J.]]

[[Category: Uppsten M]]

[[Category: Uppsten, M.]]

[[Category: Wallden K]]

[[Category: Wallden, K.]]

[[Category: Weigelt J]]

[[Category: Weigelt, J.]]

[[Category: Van Den Berg S]]

[[Category: ~~AMP]]~~

~~[[Category: CL]]~~

~~[[Category: GOL]]~~

~~[[Category: adenylosuccinase]]~~

~~[[Category: adenylosuccinase deficiency]]~~

~~[[Category: adenylosuccinate lyase]]~~

~~[[Category: adsl]]~~

~~[[Category: alternative splicing]]~~

~~[[Category: amp]]~~

~~[[Category: disease mutation]]~~

~~[[Category: epilepsy]]~~

~~[[Category: lyase]]~~

~~[[Category: purine]]~~

~~[[Category: purine biosynthesis]]~~

~~[[Category: s-amp]]~~

~~[[Category: saicar]]~~

~~[[Category: succino amp-lyase~~]]

~~''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:19:29 2007''~~

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@@ Line 1: / Line 1: @@
-[[Image:2j91.gif|left|200px]]<br />
-<applet load="2j91" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2j91, resolution 1.80&Aring;" />
-'''CRYSTAL STRUCTURE OF HUMAN ADENYLOSUCCINATE LYASE IN COMPLEX WITH AMP'''<br />
-==About this Structure==
+==Crystal structure of Human Adenylosuccinate Lyase in complex with AMP==
-J91 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, AMP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. This structure superseeds the now removed PDB entry 2J84. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.2 4.3.2.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J91 OCA]].
+<StructureSection load='2j91' size='340' side='right'caption='[[2j91]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2j91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2j84 2j84]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J91 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j91 OCA], [https://pdbe.org/2j91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j91 RCSB], [https://www.ebi.ac.uk/pdbsum/2j91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j91 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PUR8_HUMAN PUR8_HUMAN] Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency) [MIM:[https://omim.org/entry/103050 103050]. ADSL deficiency is an autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present.
+== Function ==
+[https://www.uniprot.org/uniprot/PUR8_HUMAN PUR8_HUMAN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/2j91_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j91 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Adenylosuccinate lyase 3D structures|Adenylosuccinate lyase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Berg, S.Van.Den.]]
+[[Category: Berglund H]]
-[[Category: Berglund, H.]]
+[[Category: Busam R]]
-[[Category: Busam, R.]]
+[[Category: Collins R]]
-[[Category: Collins, R.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Ericsson UB]]
-[[Category: Ericsson, U.B.]]
+[[Category: Flodin S]]
-[[Category: Flodin, S.]]
+[[Category: Flores A]]
-[[Category: Flores, A.]]
+[[Category: Graslund S]]
-[[Category: Graslund, S.]]
+[[Category: Hallberg BM]]
-[[Category: Hallberg, B.M.]]
+[[Category: Hammarstrom M]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hogbom M]]
-[[Category: Hogbom, M.]]
+[[Category: Holmberg Schiavone L]]
-[[Category: Johansson, I.]]
+[[Category: Johansson I]]
-[[Category: Karlberg, T.]]
+[[Category: Karlberg T]]
-[[Category: Kosinska, U.]]
+[[Category: Kosinska U]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova T]]
-[[Category: Magnusdottir, A.]]
+[[Category: Magnusdottir A]]
-[[Category: Moche, M.]]
+[[Category: Moche M]]
-[[Category: Nilsson, M.E.]]
+[[Category: Nilsson ME]]
-[[Category: Nilsson-Ehle, P.]]
+[[Category: Nilsson-Ehle P]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman T]]
-[[Category: Ogg, D.]]
+[[Category: Ogg D]]
-[[Category: Persson, C.]]
+[[Category: Persson C]]
-[[Category: Sagemark, J.]]
+[[Category: Sagemark J]]
-[[Category: Schiavone, L.Holmberg.]]
+[[Category: Stenmark P]]
-[[Category: Stenmark, P.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Thorsell AG]]
-[[Category: Thorsell, A.G.]]
+[[Category: Uppenberg J]]
-[[Category: Uppenberg, J.]]
+[[Category: Uppsten M]]
-[[Category: Uppsten, M.]]
+[[Category: Wallden K]]
-[[Category: Wallden, K.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Van Den Berg S]]
-[[Category: AMP]]
-[[Category: CL]]
-[[Category: GOL]]
-[[Category: adenylosuccinase]]
-[[Category: adenylosuccinase deficiency]]
-[[Category: adenylosuccinate lyase]]
-[[Category: adsl]]
-[[Category: alternative splicing]]
-[[Category: amp]]
-[[Category: disease mutation]]
-[[Category: epilepsy]]
-[[Category: lyase]]
-[[Category: purine]]
-[[Category: purine biosynthesis]]
-[[Category: s-amp]]
-[[Category: saicar]]
-[[Category: succino amp-lyase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:19:29 2007''