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==The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand==
==The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand==
<StructureSection load='4bw1' size='340' side='right' caption='[[4bw1]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='4bw1' size='340' side='right'caption='[[4bw1]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bw1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BW1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bw1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BW1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw2|4bw2]], [[4bw3|4bw3]], [[4bw4|4bw4]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw1 OCA], [http://pdbe.org/4bw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4bw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bw1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw1 OCA], [https://pdbe.org/4bw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4bw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bw1 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).  
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Bromodomain-containing protein|Bromodomain-containing protein]]
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Bamborough, P]]
[[Category: Large Structures]]
[[Category: Bouillot, A]]
[[Category: Bamborough P]]
[[Category: Chung, C]]
[[Category: Bouillot A]]
[[Category: Delannee, D]]
[[Category: Chung C]]
[[Category: Dudit, Y]]
[[Category: Delannee D]]
[[Category: Gellibert, F]]
[[Category: Dudit Y]]
[[Category: Huet, P]]
[[Category: Gellibert F]]
[[Category: Krysa, G]]
[[Category: Huet P]]
[[Category: Lamotte, Y]]
[[Category: Krysa G]]
[[Category: Lewis, A]]
[[Category: Lamotte Y]]
[[Category: Mirguet, O]]
[[Category: Lewis A]]
[[Category: Nicodeme, E]]
[[Category: Mirguet O]]
[[Category: Trottet, L]]
[[Category: Nicodeme E]]
[[Category: Witherington, J]]
[[Category: Trottet L]]
[[Category: Antagonist]]
[[Category: Witherington J]]
[[Category: Epigenetic reader]]
[[Category: Histone]]
[[Category: Inhibitor]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/4bw1"