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==Crystal structure of a single mutant (N71D) of triosephosphate isomerase from human==
==Crystal structure of a single mutant (N71D) of triosephosphate isomerase from human==
<StructureSection load='4unl' size='340' side='right' caption='[[4unl]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4unl' size='340' side='right'caption='[[4unl]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4unl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UNL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4unl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UNL FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4unk|4unk]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4unl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unl OCA], [https://pdbe.org/4unl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4unl RCSB], [https://www.ebi.ac.uk/pdbsum/4unl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4unl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4unl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unl OCA], [http://pdbe.org/4unl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4unl RCSB], [http://www.ebi.ac.uk/pdbsum/4unl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4unl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[http://omim.org/entry/190450 190450]]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.  
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
== Function ==
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]


==See Also==
==See Also==
*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Triose-phosphate isomerase]]
[[Category: Homo sapiens]]
[[Category: Castillo-Villanueva, A]]
[[Category: Large Structures]]
[[Category: DeLaMora-DeLaMora, I]]
[[Category: Castillo-Villanueva A]]
[[Category: Enriquez-Flores, S]]
[[Category: DeLaMora-DeLaMora I]]
[[Category: Garcia-Torres, I]]
[[Category: Enriquez-Flores S]]
[[Category: Gomez-Manzo, S]]
[[Category: Garcia-Torres I]]
[[Category: Lopez-Velazquez, G]]
[[Category: Gomez-Manzo S]]
[[Category: Marcial-Quino, J]]
[[Category: Lopez-Velazquez G]]
[[Category: Mendez, S T]]
[[Category: Marcial-Quino J]]
[[Category: Oria-Hernandez, J]]
[[Category: Mendez ST]]
[[Category: Reyes-Vivas, H]]
[[Category: Oria-Hernandez J]]
[[Category: Torres-Arroyo, A]]
[[Category: Reyes-Vivas H]]
[[Category: Torres-Larios, A]]
[[Category: Torres-Arroyo A]]
[[Category: Deamidation]]
[[Category: Torres-Larios A]]
[[Category: Isomerase]]
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