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==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H)==
==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H)==
<StructureSection load='4hog' size='340' side='right' caption='[[4hog]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4hog' size='340' side='right'caption='[[4hog]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hog]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canga Canga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HOG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hog]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HOG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=18H:5-[3-(2-METHOXY-4-PHENYLPHENYL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4-DIAMINE'>18H</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qlr|3qlr]], [[3qls|3qls]], [[3qlw|3qlw]], [[4h95|4h95]], [[4h96|4h96]], [[4h97|4h97]], [[4h98|4h98]], [[4hoe|4hoe]], [[4hof|4hof]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18H:5-[3-(2-METHOXY-4-PHENYLPHENYL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4-DIAMINE'>18H</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hog OCA], [https://pdbe.org/4hog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hog RCSB], [https://www.ebi.ac.uk/pdbsum/4hog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hog ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hog OCA], [http://pdbe.org/4hog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hog RCSB], [http://www.ebi.ac.uk/pdbsum/4hog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hog ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6FPH0_CANGA Q6FPH0_CANGA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Canga]]
[[Category: Large Structures]]
[[Category: Anderson, A C]]
[[Category: Anderson AC]]
[[Category: Paulsen, J L]]
[[Category: Paulsen JL]]
[[Category: Antifungal agent]]
[[Category: Candida glabrata]]
[[Category: Drug design]]
[[Category: Enzyme inhibitor]]
[[Category: Fungal protein]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Structure-activity relationship]]
[[Category: Tetrahydrofolate dehydrogenase]]
Retrieved from "https://proteopedia.org/4hog"