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==Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5==
==Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5==
<StructureSection load='4oz1' size='340' side='right' caption='[[4oz1]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
<StructureSection load='4oz1' size='340' side='right'caption='[[4oz1]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4oz1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4oz1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OZ1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz1 OCA], [http://pdbe.org/4oz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz1 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz1 OCA], [https://pdbe.org/4oz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oz1 RCSB], [https://www.ebi.ac.uk/pdbsum/4oz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RBM39_HUMAN RBM39_HUMAN]] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. [[http://www.uniprot.org/uniprot/SF3B1_HUMAN SF3B1_HUMAN]] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.  
[https://www.uniprot.org/uniprot/RBM39_HUMAN RBM39_HUMAN] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kielkopf, C L]]
[[Category: Homo sapiens]]
[[Category: Loerch, S]]
[[Category: Large Structures]]
[[Category: Pre-mrna splicing factor]]
[[Category: Kielkopf CL]]
[[Category: Protein-peptide complex]]
[[Category: Loerch S]]
[[Category: U2af homology motif]]
[[Category: Uhm]]
Retrieved from "https://proteopedia.org/4oz1"