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==Molecular mechanism for self-protection against type VI secretion system in Vibrio cholerae==
==Molecular mechanism for self-protection against type VI secretion system in Vibrio cholerae==
<StructureSection load='4noo' size='340' side='right' caption='[[4noo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4noo' size='340' side='right'caption='[[4noo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4noo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NOO FirstGlance]. <br>
<table><tr><td colspan='2'>[[4noo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOO FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VC_A0123 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH]), VC_A0124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4noo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4noo OCA], [https://pdbe.org/4noo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4noo RCSB], [https://www.ebi.ac.uk/pdbsum/4noo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4noo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4noo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4noo OCA], [http://pdbe.org/4noo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4noo RCSB], [http://www.ebi.ac.uk/pdbsum/4noo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4noo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VGRG3_VIBCH VGRG3_VIBCH] Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:23362380, PubMed:23341465). Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity (PubMed:23362380). Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus (PubMed:23362380, PubMed:23341465). Toxicity is counteracted by a cognate immunity protein TsiV3 (PubMed:23362380, PubMed:24699653, PubMed:23341465).<ref>PMID:23341465</ref> <ref>PMID:23362380</ref> <ref>PMID:24699653</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibch]]
[[Category: Large Structures]]
[[Category: Fan, Z]]
[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
[[Category: Jiang, T]]
[[Category: Fan Z]]
[[Category: Xu, M]]
[[Category: Jiang T]]
[[Category: Yang, X]]
[[Category: Xu M]]
[[Category: Chitosanase-fold]]
[[Category: Yang X]]
[[Category: Glycoside hydrolase effector]]
[[Category: Immune system]]
[[Category: Immunity protein]]
[[Category: Self-protection]]
[[Category: Three-helical bundle]]
Retrieved from "https://proteopedia.org/4noo"