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==Structural Determination of BA0150, a Polysaccharide Deacetylase from Bacillus anthracis==
==Structural Determination of BA0150, a Polysaccharide Deacetylase from Bacillus anthracis==
<StructureSection load='4m1b' size='340' side='right' caption='[[4m1b]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='4m1b' size='340' side='right'caption='[[4m1b]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M1B FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m1b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M1B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ba0150, BAS0150, BA_0150, GBAA_0150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1b OCA], [http://pdbe.org/4m1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m1b RCSB], [http://www.ebi.ac.uk/pdbsum/4m1b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m1b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1b OCA], [https://pdbe.org/4m1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m1b RCSB], [https://www.ebi.ac.uk/pdbsum/4m1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m1b ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A6L7HRJ6_BACAN A0A6L7HRJ6_BACAN]
Polysaccharide deacetylases are bacterial enzymes that catalyze the deacetylation of acetylated sugars on the membranes of Gram-positive bacteria, allowing them to be unrecognized by host immune systems. Inhibition of these enzymes would disrupt such pathogenic defensive mechanisms and therefore offers a promising route for the development of novel antibiotic therapeutics. Here, the first X-ray crystal structure of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis, is reported to 2.0 A resolution. The overall structure maintains the conserved (alpha/beta)8 fold that is characteristic of this family of enzymes. The lack of a catalytic metal ion and a distinctive metal-binding site, however, suggest that this enzyme is not a functional polysaccharide deacetylase.
 
Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis.,Strunk RJ, Piemonte KM, Petersen NM, Koutsioulis D, Bouriotis V, Perry K, Cole KE Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):156-9. doi:, 10.1107/S2053230X13034262. Epub 2014 Jan 21. PMID:24637747<ref>PMID:24637747</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4m1b" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cole, K E]]
[[Category: Bacillus anthracis]]
[[Category: Perry, K]]
[[Category: Large Structures]]
[[Category: Carbohydrate esterase]]
[[Category: Cole KE]]
[[Category: Hydrolase]]
[[Category: Perry K]]
[[Category: Nobb domain]]
[[Category: Polysaccharide deacetylase]]
[[Category: Polysaccharide deacetylation]]
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