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==Neutron structure of leucine and valine methyl protonated type III antifreeze==
==Neutron structure of leucine and valine methyl protonated type III antifreeze==
<StructureSection load='4ny6' size='340' side='right' caption='[[4ny6]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4ny6' size='340' side='right'caption='[[4ny6]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ny6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NY6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ny6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zoarces_americanus Zoarces americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NY6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qf6|3qf6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ny6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ny6 OCA], [http://pdbe.org/4ny6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ny6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ny6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ny6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ny6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ny6 OCA], [https://pdbe.org/4ny6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ny6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ny6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ny6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ANP12_ZOAAM ANP12_ZOAAM]] Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth.  
[https://www.uniprot.org/uniprot/ANP12_ZOAAM ANP12_ZOAAM] Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The 1.8 A resolution neutron structure of deuterated type III antifreeze protein in which the methyl groups of leucine and valine residues are selectively protonated is presented. Comparison between this and the 1.85 A resolution neutron structure of perdeuterated type III antifreeze protein indicates that perdeuteration improves the visibility of solvent molecules located in close vicinity to hydrophobic residues, as cancellation effects between H atoms of the methyl groups and nearby heavy-water molecules (D2O) are avoided.
 
Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography.,Fisher SJ, Blakeley MP, Howard EI, Petit-Haertlein I, Haertlein M, Mitschler A, Cousido-Siah A, Salvay AG, Popov A, Muller-Dieckmann C, Petrova T, Podjarny A Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3266-72. doi:, 10.1107/S1399004714021610. Epub 2014 Nov 28. PMID:25478844<ref>PMID:25478844</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ny6" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Antifreeze protein|Antifreeze protein]]
*[[Antifreeze protein 3D structures|Antifreeze protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Blakeley, M P]]
[[Category: Large Structures]]
[[Category: Cousido-Siah, A]]
[[Category: Zoarces americanus]]
[[Category: Fisher, S J]]
[[Category: Blakeley MP]]
[[Category: Haertlein, M]]
[[Category: Cousido-Siah A]]
[[Category: Howard, E I]]
[[Category: Fisher SJ]]
[[Category: Mitschler, A]]
[[Category: Haertlein M]]
[[Category: Muller-Dieckmann, C]]
[[Category: Howard EI]]
[[Category: Petite-Haertlein, I]]
[[Category: Mitschler A]]
[[Category: Petrova, T]]
[[Category: Muller-Dieckmann C]]
[[Category: Podjarny, A D]]
[[Category: Petite-Haertlein I]]
[[Category: Popov, A]]
[[Category: Petrova T]]
[[Category: Salvaya, A G]]
[[Category: Podjarny AD]]
[[Category: Antifreeze protein]]
[[Category: Popov A]]
[[Category: Salvaya AG]]
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