4nf9: Difference between revisions

<StructureSection load='4nf9' size='340' side='right'caption='[[4nf9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[4nf9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NF9 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nf9 OCA], [https://pdbe.org/4nf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nf9 RCSB], [https://www.ebi.ac.uk/pdbsum/4nf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nf9 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KNL1_HUMAN KNL1_HUMAN] Autosomal recessive primary microcephaly. A chromosomal aberration involving KNL1 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A. May give rise to a KMT2A-KNL1 fusion protein.<ref>PMID:12618766</ref>  The disease is caused by variants affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/KNL1_HUMAN KNL1_HUMAN] Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.<ref>PMID:15502821</ref> <ref>PMID:17981135</ref> <ref>PMID:18045986</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Keller J]]

[[Category: Mattiuzzo M]]

[[Category: Mosalaganti S]]

[[Category: Musacchio A]]

[[Category: Overlack K]]

[[Category: Pasqualato S]]

[[Category: Petrovic A]]

[[Category: Raunser S]]

[[Category: Wohlgemuth S]]