2vvx: Difference between revisions
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== | ==Structure of Vaccinia virus protein A52== | ||
<StructureSection load='2vvx' size='340' side='right' caption='[[2vvx]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='2vvx' size='340' side='right'caption='[[2vvx]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vvx]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2vvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VVX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.746Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vvx OCA], [https://pdbe.org/2vvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vvx RCSB], [https://www.ebi.ac.uk/pdbsum/2vvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vvx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A52_VACCW A52_VACCW] Bcl-2-like protein which targets host toll-like receptor signaling complexes to suppress innate immune response. Interacts with host TRAF6 to activate p38 and subsequently induce the expression of several cytokines such as IL-10. Associates also with host IRAK2 to inhibit NF-kappa-B signaling.<ref>PMID:12566418</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vvx_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vvx_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
[[Category: Abrescia | [[Category: Abrescia NGA]] | ||
[[Category: Alderton | [[Category: Alderton D]] | ||
[[Category: Bahar | [[Category: Bahar MW]] | ||
[[Category: Chen | [[Category: Chen RA-J]] | ||
[[Category: Cooray | [[Category: Cooray S]] | ||
[[Category: Graham | [[Category: Graham SC]] | ||
[[Category: Grimes | [[Category: Grimes JM]] | ||
[[Category: Owens | [[Category: Owens RJ]] | ||
[[Category: Smith | [[Category: Smith GL]] | ||
[[Category: Stuart | [[Category: Stuart DI]] | ||
[[Category: Whalen | [[Category: Whalen DM]] | ||
