Selectin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (3 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1g1r' size=' | <StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'> | ||
== Function == | == Function == | ||
'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br /> | '''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br /> | ||
| Line 10: | Line 10: | ||
== Structural insight == | == Structural insight == | ||
The <scene name='55/552185/Cv/ | The <scene name='55/552185/Cv/4'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/5'>Ca coordination site</scene>. | ||
</StructureSection> | </StructureSection> | ||
| Line 29: | Line 29: | ||
**[[3cfw]] – hCD62L EGF domain <br /> | **[[3cfw]] – hCD62L EGF domain <br /> | ||
**[[5vc1]] – hCD62L EGF domain (mutant)<br /> | |||
**[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br /> | **[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br /> | ||
| Line 36: | Line 37: | ||
**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br /> | **[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br /> | ||
**[[4c16]] – hCD62 EGF+SCR domains + antagonist <br /> | **[[4c16]] – hCD62 EGF+SCR domains + antagonist <br /> | ||
**[[4csy]] | **[[4csy]], [[6eyi]], [[6eyj]], [[6eyk]] - hCD62 EGF+SCR domains + ligand <br /> | ||
}} | }} | ||
