TATA-Binding Protein: Difference between revisions

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<StructureSection load='1tgh' size='350' side='right' scene='' caption='Human TATA-binding protein dimer complex with DNA TATA box (PDB code [[1tgh]])'>
<StructureSection load='1tgh' size='350' side='right' scene='' caption='Human TATA-binding protein complex with DNA TATA box (PDB code [[1tgh]])'>
== Function ==
== Function ==
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex.  The transcription factor proteins are named TFIIA to TFIIH.  TBP is part of TFIID.  Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>.  Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif.  See also<br />
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex.  The transcription factor proteins are named TFIIA to TFIIH.  TBP is part of TFIID.  Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>.  Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif.  See also<br />
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<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.  
<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.  


The interactions of TBP with the DNA TATA box occurs with the minor groove of the DNA.  The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>.
The interactions of <scene name='10/100866/Cv/2'>TBP with the DNA TATA box occurs with the minor groove of the DNA</scene>.  The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>.


{{Clear}}
{{Clear}}
</StructureSection>


== 3D Structures of TATA-binding protein ==
== 3D Structures of TATA-binding protein ==
[[TATA-binding protein 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* TBP
 
**[[2z8u]] – TBP – ''Methanococcus janaschii''<br />
**[[1pcz]] – PwTBP - ''Pyrococcus woesei''<br />
**[[1vok]] – AtTBP - ''Arabidopsis thaliana''<br />
**[[1tbp]] – yTBP - yeast<br />
**[[4b04]] – yTBP (mutant)<br />
**[[1mp9]] – TBP – ''Sulfolobus acidocaldarius''<br />
**[[3eik]] – TBP – ''Encephalitozoon cuniculi''
 
* TBP+DNA TATA box
 
**[[1ytb]] - yTBP + DNA TATA<br />
**[[1cdw]] - hTBP core domain+ DNA TATA - human<br />
**[[1tgh]] - hTBP + DNA TATA<br />
**[[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]], [[1qn3]], [[1qn4]], [[1vto]] - AtTBP + DNA TATA <br />
 
* TBP+DNA TATA box +TFIIA
 
**[[1rm1]] – yTBP+TFIIA α, β, γ chains+ DNA TATA <br />
**[[1ytf]] - yTBP+TFIIA + DNA TATA<br />
**[[1nh2]] – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA<br />
**[[1nvp]] - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA <br />
**[[1jfi]] - hTBP C-terminal+ TFIIA NC2+ DNA TATA<br />
 
* TBP+DNA TATA box +TFIIB


**[[1ngm]] - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA<br />
**[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
**[[1c9b]] - hTBP C-terminal+TFIIBC+adenovirus major late promoter<br />
**[[1vol]] – AtTBP+hTFIIB+DNA TATA<br />
**[[1ais]], [[1d3u]] - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA <br />
**[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 09:33, 13 February 2020

Human TATA-binding protein complex with DNA TATA box (PDB code 1tgh)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Ala Jelani, Alexander Berchansky, David Canner, Michal Harel, Eran Hodis

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