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==Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP==
==Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP==
<StructureSection load='5agr' size='340' side='right' caption='[[5agr]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='5agr' size='340' side='right'caption='[[5agr]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5agr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGR FirstGlance]. <br>
<table><tr><td colspan='2'>[[5agr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AGR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A52:3-AMINOMETHYL-7-(ETHOXY)-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A52</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ags|5ags]], [[5agt|5agt]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A52:3-AMINOMETHYL-7-(ETHOXY)-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A52</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5agr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agr OCA], [https://pdbe.org/5agr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5agr RCSB], [https://www.ebi.ac.uk/pdbsum/5agr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5agr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agr OCA], [http://pdbe.org/5agr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5agr RCSB], [http://www.ebi.ac.uk/pdbsum/5agr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5agr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYL_MYCTU SYL_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5agr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5agr" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Leucine--tRNA ligase]]
[[Category: Large Structures]]
[[Category: Alley, M R.K]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Barros, D]]
[[Category: Alley MRK]]
[[Category: Cooper, C B]]
[[Category: Barros D]]
[[Category: Cusack, S]]
[[Category: Cooper CB]]
[[Category: Ding, C]]
[[Category: Cusack S]]
[[Category: Easom, E E]]
[[Category: Ding C]]
[[Category: Franzblau, S G]]
[[Category: Easom EE]]
[[Category: Hernandez, V]]
[[Category: Franzblau SG]]
[[Category: Lenaerts, A J]]
[[Category: Hernandez V]]
[[Category: Li, X]]
[[Category: Lenaerts AJ]]
[[Category: Ma, Z]]
[[Category: Li X]]
[[Category: Meewan, M]]
[[Category: Ma Z]]
[[Category: Mendoza, A]]
[[Category: Meewan M]]
[[Category: Mohan, M]]
[[Category: Mendoza A]]
[[Category: Palencia, A]]
[[Category: Mohan M]]
[[Category: Parish, T]]
[[Category: Palencia A]]
[[Category: Plattner, J J]]
[[Category: Parish T]]
[[Category: Rock, F L]]
[[Category: Plattner JJ]]
[[Category: Wang, Y]]
[[Category: Rock FL]]
[[Category: Waters, M G]]
[[Category: Wang Y]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Waters MG]]
[[Category: Ligase]]
[[Category: Novel boron inhibitors of leur]]
[[Category: Protein biosynthesis]]
Retrieved from "https://proteopedia.org/5agr"