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==Crystal structure of M. tuberculosis lipoyl synthase at 1.64 A resolution==
==Crystal structure of M. tuberculosis lipoyl synthase at 1.64 A resolution==
<StructureSection load='5exj' size='340' side='right' caption='[[5exj]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
<StructureSection load='5exj' size='340' side='right'caption='[[5exj]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5exj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EXJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5exj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EXJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5exi|5exi]], [[5exk|5exk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoyl_synthase Lipoyl synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.8 2.8.1.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5exj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5exj OCA], [https://pdbe.org/5exj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5exj RCSB], [https://www.ebi.ac.uk/pdbsum/5exj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5exj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5exj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5exj OCA], [http://pdbe.org/5exj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5exj RCSB], [http://www.ebi.ac.uk/pdbsum/5exj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5exj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LIPA_MYCTU LIPA_MYCTU]] Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.  
[https://www.uniprot.org/uniprot/LIPA_MYCTU LIPA_MYCTU] Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lipoyl synthase]]
[[Category: Large Structures]]
[[Category: Booker, S J]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Drennan, C L]]
[[Category: Booker SJ]]
[[Category: Goldman, P J]]
[[Category: Drennan CL]]
[[Category: Lanz, N D]]
[[Category: Goldman PJ]]
[[Category: Lee, K H]]
[[Category: Lanz ND]]
[[Category: McLaughlin, M I]]
[[Category: Lee K-H]]
[[Category: Adomet radical]]
[[Category: McLaughlin MI]]
[[Category: Auxiliary iron-sulfur cluster]]
[[Category: Radical sam]]
[[Category: Sulfur insertion]]
[[Category: Transferase]]
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