5grj: Difference between revisions
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New page: '''Unreleased structure''' The entry 5grj is ON HOLD Authors: Liu, K., Tan, S., Chai, Y., Chen, D., Song, H., Zhang, C.W.-H., Shi, Y., Liu, J., Tan, W., Lyu, J., Gao, S., Yan, J., Qi, J... |
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==Crystal structure of human PD-L1 with monoclonal antibody avelumab== | |||
<StructureSection load='5grj' size='340' side='right'caption='[[5grj]], [[Resolution|resolution]] 3.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5grj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GRJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.206Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5grj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grj OCA], [https://pdbe.org/5grj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5grj RCSB], [https://www.ebi.ac.uk/pdbsum/5grj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5grj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | |||
==See Also== | |||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chai Y]] | ||
[[Category: | [[Category: Chen D]] | ||
[[Category: | [[Category: Gao GF]] | ||
[[Category: | [[Category: Gao S]] | ||
[[Category: | [[Category: Liu J]] | ||
[[Category: | [[Category: Liu K]] | ||
[[Category: | [[Category: Lyu J]] | ||
[[Category: | [[Category: Qi J]] | ||
[[Category: | [[Category: Shi Y]] | ||
[[Category: | [[Category: Song H]] | ||
[[Category: Tan S]] | |||
[[Category: Tan W]] | |||
[[Category: Yan J]] | |||
[[Category: Zhang CW-H]] | |||
Latest revision as of 11:40, 2 August 2023
Crystal structure of human PD-L1 with monoclonal antibody avelumab
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