5gs9: Difference between revisions

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'''Unreleased structure'''


The entry 5gs9 is ON HOLD
==Crystal structure of CASTOR1-arginine==
 
<StructureSection load='5gs9' size='340' side='right'caption='[[5gs9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors: Zhang, T., Ding, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5gs9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GS9 FirstGlance]. <br>
Description: Crystal structure of C1-R
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
[[Category: Zhang, T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gs9 OCA], [https://pdbe.org/5gs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gs9 RCSB], [https://www.ebi.ac.uk/pdbsum/5gs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gs9 ProSAT]</span></td></tr>
[[Category: Ding, J]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAST1_HUMAN CAST1_HUMAN] Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058). As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1 (PubMed:26972053, PubMed:27487210, PubMed:33594058). Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058).<ref>PMID:26972053</ref> <ref>PMID:27487210</ref> <ref>PMID:33594058</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ding J]]
[[Category: Zhang T]]
Retrieved from "https://proteopedia.org/5gs9"