5lqu: Difference between revisions

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New page: '''Unreleased structure''' The entry 5lqu is ON HOLD Authors: Ehler, A., Lerner, C., Ellermann, M., Rudolph, M.G. Description: Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3...
 
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'''Unreleased structure'''


The entry 5lqu is ON HOLD
==Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-[6-(ethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide==
<StructureSection load='5lqu' size='340' side='right'caption='[[5lqu]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LQU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=619:N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ETHYLAMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>619</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqu OCA], [https://pdbe.org/5lqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lqu RCSB], [https://www.ebi.ac.uk/pdbsum/5lqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.


Authors: Ehler, A., Lerner, C., Ellermann, M., Rudolph, M.G.
==See Also==
 
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
Description: Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-[6-(ethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Ehler, A]]
[[Category: Large Structures]]
[[Category: Ellermann, M]]
[[Category: Rattus norvegicus]]
[[Category: Rudolph, M.G]]
[[Category: Ehler A]]
[[Category: Lerner, C]]
[[Category: Ellermann M]]
[[Category: Lerner C]]
[[Category: Rudolph MG]]
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