1oj8: Difference between revisions

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[[Image:1oj8.gif|left|200px]]


{{Structure
==Novel and retro Binding Modes in Cytotoxic Ribonucleases from Rana catesbeiana of Two Crystal Structures Complexed with d(ApCpGpA) and (2',5'CpG)==
|PDB= 1oj8 |SIZE=350|CAPTION= <scene name='initialview01'>1oj8</scene>, resolution 1.7&Aring;
<StructureSection load='1oj8' size='340' side='right'caption='[[1oj8]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[1oj8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_catesbeianus Lithobates catesbeianus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OJ8 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oj8 OCA], [https://pdbe.org/1oj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oj8 RCSB], [https://www.ebi.ac.uk/pdbsum/1oj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oj8 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oj8 OCA], [http://www.ebi.ac.uk/pdbsum/1oj8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oj8 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q9DFY5_AQUCT Q9DFY5_AQUCT]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/1oj8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oj8 ConSurf].
<div style="clear:both"></div>


'''NOVEL AND RETRO BINDING MODES IN CYTOTOXIC RIBONUCLEASES FROM RANA CATESBEIANA OF TWO CRYSTAL STRUCTURES COMPLEXED WITH D(APCPGPA) AND (2',5'CPG)'''
==See Also==
 
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1OJ8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OJ8 OCA].
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Lithobates catesbeianus]]
[[Category: Rana catesbeiana]]
[[Category: Chen L-Y]]
[[Category: Chen, L Y.]]
[[Category: Cheng P-T]]
[[Category: Cheng, P T.]]
[[Category: Liao Y-D]]
[[Category: Liao, Y D.]]
[[Category: Liu J-H]]
[[Category: Liu, J H.]]
[[Category: Sun Y-J]]
[[Category: Sun, Y J.]]
[[Category: Tsai C-J]]
[[Category: Tsai, C J.]]
[[Category: anti-tumor activity]]
[[Category: cytotoxic ribonuclease]]
[[Category: hydrolase]]
[[Category: sialic binding and nucleotide binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:46:07 2008''

Latest revision as of 04:47, 17 October 2024

Novel and retro Binding Modes in Cytotoxic Ribonucleases from Rana catesbeiana of Two Crystal Structures Complexed with d(ApCpGpA) and (2',5'CpG)

1oj8, resolution 1.70Å

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