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==A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property==
==A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property==
<StructureSection load='2nd4' size='340' side='right' caption='[[2nd4]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2nd4' size='340' side='right'caption='[[2nd4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2nd4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ND4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ND4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2nd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_parasanguinis_FW213 Streptococcus parasanguinis FW213]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ND4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ND4 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nd4 OCA], [http://pdbe.org/2nd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2nd4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nd4 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nd4 OCA], [https://pdbe.org/2nd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2nd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nd4 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/I1ZJ30_STRPA I1ZJ30_STRPA]
Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness and virulence. We found a unique gene locus encoding an amylase-binding adhesin AbpA and a sortase B in oral streptococci. AbpA possesses a new distinct C-terminal cell wall sorting signal. We demonstrated that this C-terminal motif is required for anchoring AbpA to cell wall. In vitro and in vivo studies revealed that SrtB has dual functions, anchoring AbpA to the cell wall and processing AbpA into a ladder profile. Solution structure of AbpA determined by NMR reveals a novel structure comprising a small globular alpha/beta domain and an extended coiled-coil heliacal domain. Structural and biochemical studies identified key residues that are crucial for amylase binding. Taken together, our studies document a unique sortase/adhesion substrate system in streptococci adapted to the oral environment rich in salivary amylase.
 
A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property.,Liang X, Liu B, Zhu F, Scannapieco FA, Haase EM, Matthews S, Wu H Sci Rep. 2016 Aug 5;6:30966. doi: 10.1038/srep30966. PMID:27492581<ref>PMID:27492581</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2nd4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Liu, B]]
[[Category: Large Structures]]
[[Category: Matthews, S]]
[[Category: Streptococcus parasanguinis FW213]]
[[Category: Wu, H]]
[[Category: Liu B]]
[[Category: Zhu, F]]
[[Category: Matthews S]]
[[Category: Hydrolase receptor]]
[[Category: Wu H]]
[[Category: Novel fold]]
[[Category: Zhu F]]

Latest revision as of 07:04, 1 May 2024

A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property

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