5j03: Difference between revisions

<StructureSection load='5j03' size='340' side='right'caption='[[5j03]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[5j03]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J03 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j03 OCA], [https://pdbe.org/5j03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j03 RCSB], [https://www.ebi.ac.uk/pdbsum/5j03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j03 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KCNQ3_HUMAN KCNQ3_HUMAN] Benign familial infantile epilepsy;Benign familial neonatal seizures;Juvenile myoclonic epilepsy. The disease is caused by mutations affecting the gene represented in this entry.  Defects in KCNQ3 may be involved in epileptic disorders. These are characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system.<ref>PMID:22612257</ref>  

[https://www.uniprot.org/uniprot/KCNQ2_HUMAN KCNQ2_HUMAN] [https://www.uniprot.org/uniprot/KCNQ3_HUMAN KCNQ3_HUMAN] Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Hirsch JA]]

[[Category: Strulovich R]]