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==SeMet Derivative of L512M mutant of PASTA domain 3 of Mycobacterium tuberculosis PknB==
==SeMet Derivative of L512M mutant of PASTA domain 3 of Mycobacterium tuberculosis PknB==
<StructureSection load='3ouv' size='340' side='right' caption='[[3ouv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3ouv' size='340' side='right'caption='[[3ouv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ouv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUV FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ouv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OUV FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.004&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pknB, MRA_0016 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ouv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouv OCA], [http://pdbe.org/3ouv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ouv RCSB], [http://www.ebi.ac.uk/pdbsum/3ouv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ouv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ouv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouv OCA], [https://pdbe.org/3ouv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ouv RCSB], [https://www.ebi.ac.uk/pdbsum/3ouv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ouv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PKNB_MYCTU PKNB_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:15978616</ref> <ref>PMID:15987910</ref> <ref>PMID:16817899</ref> <ref>PMID:16980473</ref> <ref>PMID:16436437</ref> <ref>PMID:19826007</ref> <ref>PMID:19121323</ref> <ref>PMID:20025669</ref> <ref>PMID:21423706</ref> <ref>PMID:22275220</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycta]]
[[Category: Large Structures]]
[[Category: Alber, T]]
[[Category: Mycobacterium tuberculosis H37Ra]]
[[Category: Chen, T Y]]
[[Category: Alber T]]
[[Category: Prigozhin, D M]]
[[Category: Chen TY]]
[[Category: Protein-ligand interaction]]
[[Category: Prigozhin DM]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3ouv"