5t4v: Difference between revisions
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==Crystal structure of the bromodomain of human BRPF1 in complex with NI-48 ligand== | |||
<StructureSection load='5t4v' size='340' side='right'caption='[[5t4v]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5t4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T4V FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=N48:4-CYANO-N-(7-METHOXY-1,4-DIMETHYL-2-OXO-1,2-DIHYDROQUINOLIN-6-YL)BENZENE-1-SULFONAMIDE'>N48</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4v OCA], [https://pdbe.org/5t4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t4v RCSB], [https://www.ebi.ac.uk/pdbsum/5t4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4v ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | |||
==See Also== | |||
*[[Peregrin|Peregrin]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bayle ED]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Brennan PE]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: | [[Category: Fedorov O]] | ||
[[Category: | [[Category: Fish P]] | ||
[[Category: | [[Category: Igoe N]] | ||
[[Category: | [[Category: Knapp S]] | ||
[[Category: | [[Category: Mathea S]] | ||
[[Category: | [[Category: Muller S]] | ||
[[Category: Tallant | [[Category: Newman JA]] | ||
[[Category: | [[Category: Nunez-Alonso G]] | ||
[[Category: Savitsky P]] | |||
[[Category: Tallant C]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 15:36, 6 March 2024
Crystal structure of the bromodomain of human BRPF1 in complex with NI-48 ligand
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