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==HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP)==
==HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP)==
<StructureSection load='5khi' size='340' side='right' caption='[[5khi]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5khi' size='340' side='right'caption='[[5khi]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5khi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KHI FirstGlance]. <br>
<table><tr><td colspan='2'>[[5khi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KHI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6SX:PURINE+RIBOSIDE-3,5-CYCLIC+MONOPHOSPHATE'>6SX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6SX:PURINE+RIBOSIDE-3,5-CYCLIC+MONOPHOSPHATE'>6SX</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5khg|5khg]], [[5khh|5khh]], [[5khj|5khj]], [[5khk|5khk]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5khi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khi OCA], [https://pdbe.org/5khi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5khi RCSB], [https://www.ebi.ac.uk/pdbsum/5khi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5khi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5khi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khi OCA], [http://pdbe.org/5khi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khi RCSB], [http://www.ebi.ac.uk/pdbsum/5khi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>
[https://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5khi" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5khi" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Accili, E A]]
[[Category: Large Structures]]
[[Category: Baronas, V]]
[[Category: Mus musculus]]
[[Category: Ng, L C.T]]
[[Category: Accili EA]]
[[Category: Petegem, F Van]]
[[Category: Baronas V]]
[[Category: Putrenko, I]]
[[Category: Ng LCT]]
[[Category: Cycilc nucleotide binding domain]]
[[Category: Putrenko I]]
[[Category: Ion transport]]
[[Category: Van Petegem F]]
[[Category: Protein-ligand complex]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/5khi"