Transferrin: Difference between revisions

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<StructureSection load='3qyt' size='350' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene=''>
<StructureSection load='' size='350' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
== Function ==
== Function ==
'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein.  TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>.  '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white.  For details see [[Molecular Playground/Transferrin]].
'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein.  TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>.  '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white.  For details see [[Molecular Playground/Transferrin]].
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== Structural highlights ==
== Structural highlights ==


TF contains two lobes: at the N  and C termini.  The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
TF contains <scene name='48/480879/Cv/7'>two lobes</scene>: at the N  and C termini.  The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
</StructureSection>
*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
== 3D Structures of Transferrin ==
== 3D Structures of Transferrin ==
[[Transferrin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Transferrin
 
**[[1jnf]] – rTF - rabbit<br />
**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />
**[[4x1d]] – hTF + Yb+3 <br />
**[[4h0w]] – hTF + Fe+3 + Bi+3<br />
**[[1suv]] – hTF + TF receptor <br />
**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
**[[1h76]] – TF - pig
 
*Transferrin N lobe
 
**[[1tfd]] – rTF N terminal<br />
**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
**[[1ryo]] - hTF N terminal + oxalate
 
*Transferrin C lobe
 
**[[3skp]] – hTF C terminal<br />
 
*Apo transferrin
 
**[[1bp5]], [[1btj]] - hTF N terminal<br />
**[[2hau]], [[2hav]] – hTF (mutant)
 
*Ovotransferrin
 
**[[1ovt]], [[1n04]] – cOTF + Fe+3 - chicken<br />
**[[2d3i]] – cOTF + Al+3<br />
**[[1dot]] – dOTF + Fe+3 - duck
 
*Ovotransferrin N lobe
 
**[[1ovb]], [[1gv8]] – dOTF NII domain <br />
**[[1gvc]] - dOTF NII domain + nitrilotriacetate<br />
**[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br />
 
*Apo ovotransferrin


**[[1aov]] – dOTF<br />
**[[1aiv]], [[1ryx]]– cOTF<br />
**[[1tfa]] - cOTF N terminal<br />
**[[1iq7]] - cOTF C terminal<br />
**[[1lfc]] – OTF residues 17-41 – bovine - NMR
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 08:37, 5 March 2020

Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code 3qyt).

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References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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