5ta2: Difference between revisions

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'''Unreleased structure'''


The entry 5ta2 is ON HOLD
==Discovery of a Potent Cyclophilin Inhibitor (Compound 7) based on Structural Simplification of Sanglifehrin A==
<StructureSection load='5ta2' size='340' side='right'caption='[[5ta2]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ta2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TA2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=78X:11-[(3-HYDROXYPHENYL)METHYL]-18-METHOXY-2,17-DIMETHYL-14-(PROPAN-2-YL)-3-OXA-9,12,15,28-TETRAAZATRICYCLO[21.3.1.1~5,9~]OCTACOSA-1(27),21,23,25-TETRAENE-4,10,13,16-TETRONE'>78X</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ta2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ta2 OCA], [https://pdbe.org/5ta2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ta2 RCSB], [https://www.ebi.ac.uk/pdbsum/5ta2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ta2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


Authors: Appleby, T.C., Steadman, V., Pettit, S., Schmitz, U., Mackman, R.L., Schultz, B.
==See Also==
 
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
Description: Discovery of a Potent Cyclophilin Inhibitor (Compound 6) based on Structural Simplification of Sanglifehrin A
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Pettit, S]]
[[Category: Homo sapiens]]
[[Category: Mackman, R.L]]
[[Category: Large Structures]]
[[Category: Schmitz, U]]
[[Category: Appleby TC]]
[[Category: Appleby, T.C]]
[[Category: Mackman RL]]
[[Category: Schultz, B]]
[[Category: Pettit S]]
[[Category: Steadman, V]]
[[Category: Schmitz U]]
[[Category: Schultz B]]
[[Category: Steadman V]]
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