5t9j: Difference between revisions
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New page: ==Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface== <StructureSection load='5t9j' size='340' side='right' caption='5t9j, [[Resolution|reso... |
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==Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface== | ==Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface== | ||
<StructureSection load='5t9j' size='340' side='right' caption='[[5t9j]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='5t9j' size='340' side='right'caption='[[5t9j]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5t9j]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T9J OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5t9j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T9J FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0001273Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t9j OCA], [https://pdbe.org/5t9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t9j RCSB], [https://www.ebi.ac.uk/pdbsum/5t9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t9j ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GEN_HUMAN GEN_HUMAN] Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.<ref>PMID:19020614</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Biertumpfel C]] | ||
[[Category: | [[Category: Lee S-H]] | ||
Latest revision as of 12:19, 9 May 2024
Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface
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