Tryptase: Difference between revisions
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<StructureSection load='2zeb' size='350' side='right' caption='Human tryptase β-2 tetramer complex with piperidine derivative inhibitor, [[2zeb]]' scene='46/465443/Cv/1' pspeed='8'> | |||
<StructureSection load='2zeb' size=' | |||
== Function == | == Function == | ||
'''Tryptase''' (TRP) is a serine protease found in mast cells<ref>PMID:15200544</ref>. | '''Tryptase''' (TRP) is a serine protease found in mast cells<ref>PMID:15200544</ref>. | ||
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== Structural highlights == | == Structural highlights == | ||
The piperidine derivative TRP inhibitor interacts with both subunits of TRP<ref>PMID:18272363</ref>. | The biological assembly of Human tryptase is <scene name='46/465443/Cv/5'>homotetramer</scene> ([[2zeb]]). The <scene name='46/465443/Cv/6'>piperidine derivative TRP inhibitor interacts with both subunits of TRP</scene><ref>PMID:18272363</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of tryptase == | == 3D Structures of tryptase == | ||
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**[[1lto]] – hTRP-α1 - human<br /> | **[[1lto]] – hTRP-α1 - human<br /> | ||
**[[2f9o]] - hTRP-α1 (mutant) | **[[2f9o]] - hTRP-α1 (mutant)<br /> | ||
**[[5wi6]] - hTRP-α/β1 (mutant)<br /> | |||
*Tryptase complex with inhibitor | *Tryptase complex with inhibitor | ||
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**[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin<br /> | **[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin<br /> | ||
**[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative<br /> | **[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative<br /> | ||
**[[4a6l]] - hTRP-α/β1 + piperidine derivative<br /> | **[[5f03]] - hTRP-β2 + oxazolidine derivative<br /> | ||
**[[4a6l]], [[6p0p]] - hTRP-α/β1 + piperidine derivative<br /> | |||
**[[4mpu]], [[4mpv]], [[4mpw]], [[4mpx]], [[4mqa]] - hTRP-α/β1 + drug<br /> | **[[4mpu]], [[4mpv]], [[4mpw]], [[4mpx]], [[4mqa]] - hTRP-α/β1 + drug<br /> | ||
**[[6vvu]] - hTRP-α/1 + antibody<br /> | |||
**[[6o1f]] - hTRP-α/β1 + trypsin inhibitor + antibody<br /> | |||
**[[2fxr]] - hTRP-β2 + ketone inhibitor<br /> | **[[2fxr]] - hTRP-β2 + ketone inhibitor<br /> | ||
**[[2fpz]] - hTRP-β2 + benzimidazole inhibitor<br /> | **[[2fpz]] - hTRP-β2 + benzimidazole inhibitor<br /> | ||
Latest revision as of 10:07, 28 January 2024
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3D Structures of tryptase
Updated on 28-January-2024
