5tc3: Difference between revisions

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'''Unreleased structure'''


The entry 5tc3 is ON HOLD  until Paper Publication
==Structure of IMP dehydrogenase from Ashbya gossypii bound to ATP and GDP==
<StructureSection load='5tc3' size='340' side='right'caption='[[5tc3]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5tc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eremothecium_gossypii_ATCC_10895 Eremothecium gossypii ATCC 10895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TC3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.462&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tc3 OCA], [https://pdbe.org/5tc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tc3 RCSB], [https://www.ebi.ac.uk/pdbsum/5tc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tc3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q756Z6_EREGS Q756Z6_EREGS] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_03156]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Inosine-5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme from the industrial fungus Ashbya gossypii, we demonstrate that the binding of adenine and guanine nucleotides to the canonical nucleotide binding sites of the regulatory Bateman domain induces different enzyme conformations with significantly distinct catalytic activities. Thereby, the comparison of their high-resolution structures defines the mechanistic and structural details of a nucleotide-controlled conformational switch that allosterically modulates the catalytic activity of eukaryotic IMPDHs. Remarkably, retinopathy-associated mutations lie within the mechanical hinges of the conformational change, highlighting its physiological relevance. Our results expand the mechanistic repertoire of Bateman domains and pave the road to new approaches targeting IMPDHs.


Authors:  
A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.,Buey RM, Fernandez-Justel D, Marcos-Alcalde I, Winter G, Gomez-Puertas P, de Pereda JM, Luis Revuelta J Sci Rep. 2017 Jun 1;7(1):2648. doi: 10.1038/s41598-017-02805-x. PMID:28572600<ref>PMID:28572600</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 5tc3" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Eremothecium gossypii ATCC 10895]]
[[Category: Large Structures]]
[[Category: Buey RM]]
[[Category: Fernandez-Justel D]]
[[Category: Revuelta JL]]
[[Category: De Pereda JM]]
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