5cyj: Difference between revisions

<StructureSection load='5cyj' size='340' side='right'caption='[[5cyj]], [[Resolution|resolution]] 1.79&Aring;' scene=''>

<table><tr><td colspan='2'>[[5cyj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CYJ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyj OCA], [https://pdbe.org/5cyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cyj RCSB], [https://www.ebi.ac.uk/pdbsum/5cyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyj ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/RBPMS_HUMAN RBPMS_HUMAN] Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.<ref>PMID:17099224</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Farazi TA]]

[[Category: Patel DJ]]

[[Category: Teplova M]]