5lyf: Difference between revisions

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New page: '''Unreleased structure''' The entry 5lyf is ON HOLD until Paper Publication Authors: Schreuder, H., Liesum, A., Loenze, P. Description: Crystal structure of 1 in complex with tafCPB [...
 
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'''Unreleased structure'''


The entry 5lyf is ON HOLD  until Paper Publication
==Crystal structure of 1 in complex with tafCPB==
<StructureSection load='5lyf' size='340' side='right'caption='[[5lyf]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lyf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LYF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7B6:(2~{S})-6-AZANYL-2-[[(2~{R})-1-[[(1~{R},2~{S},4~{S})-2-BICYCLO[2.2.1]HEPTANYL]AMINO]-3-CYCLOHEXYL-1-OXIDANYLIDENE-PROPAN-2-YL]CARBAMOYLAMINO]HEXANOIC+ACID'>7B6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyf OCA], [https://pdbe.org/5lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lyf RCSB], [https://www.ebi.ac.uk/pdbsum/5lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CBPB1_PIG CBPB1_PIG]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Previously disclosed TAFIa inhibitors having a urea zinc-binding motif were used as the starting point for the development of a novel class of highly potent inhibitors having a sulfamide zinc-binding motif. High-resolution X-ray cocrystal structures were used to optimize the structures and reveal a highly unusual sulfamide configuration. A selected sulfamide was profiled in vitro and in vivo and displayed a promising ADMET profile.


Authors: Schreuder, H., Liesum, A., Loenze, P.
Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).,Halland N, Czech J, Czechtizky W, Evers A, Follmann M, Kohlmann M, Schreuder HA, Kallus C J Med Chem. 2016 Oct 17. PMID:27749053<ref>PMID:27749053</ref>


Description: Crystal structure of 1 in complex with tafCPB
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Loenze, P]]
<div class="pdbe-citations 5lyf" style="background-color:#fffaf0;"></div>
[[Category: Liesum, A]]
 
[[Category: Schreuder, H]]
==See Also==
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Liesum A]]
[[Category: Loenze P]]
[[Category: Schreuder H]]
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