5svo: Difference between revisions

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~~'''Unreleased structure'''~~

The ~~entry 5svo~~ is ~~ON HOLD until Paper Publication~~

==Structure of IDH2 mutant R140Q==

== Structural highlights ==

<table><tr><td colspan='2'>[[5svo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVO OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5SVO FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5svo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svo OCA], [https://pdbe.org/5svo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5svo RCSB], [https://www.ebi.ac.uk/pdbsum/5svo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5svo ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/IDHP_HUMAN IDHP_HUMAN] D-2-hydroxyglutaric aciduria. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2) [MIM:[https://omim.org/entry/613657 613657]. D2HGA2 is a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.<ref>PMID:20847235</ref>

== Function ==

[https://www.uniprot.org/uniprot/IDHP_HUMAN IDHP_HUMAN] Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

~~Authors: Xie, X., Kulathila, R.~~

==See Also==

*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]

~~Description~~: ~~Structure of IDH2 mutant R140Q~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Xie, X~~]]

__TOC__

[[Category: ~~Kulathila, R~~]]

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Kulathila R]]

[[Category: Xie X]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5svo is ON HOLD  until Paper Publication
+==Structure of IDH2 mutant R140Q==
+<StructureSection load='5svo' size='340' side='right'caption='[[5svo]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5svo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SVO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5svo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svo OCA], [https://pdbe.org/5svo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5svo RCSB], [https://www.ebi.ac.uk/pdbsum/5svo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5svo ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/IDHP_HUMAN IDHP_HUMAN] D-2-hydroxyglutaric aciduria. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2) [MIM:[https://omim.org/entry/613657 613657]. D2HGA2 is a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.<ref>PMID:20847235</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/IDHP_HUMAN IDHP_HUMAN] Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
-Authors: Xie, X., Kulathila, R.
+==See Also==
+*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
-Description: Structure of IDH2 mutant R140Q
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Xie, X]]
+__TOC__
-[[Category: Kulathila, R]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kulathila R]]
+[[Category: Xie X]]