5m0t: Difference between revisions
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==Alpha-ketoglutarate-dependent non-heme iron oxygenase EasH== | |||
<StructureSection load='5m0t' size='340' side='right'caption='[[5m0t]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5m0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_japonicus Aspergillus japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M0T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m0t OCA], [https://pdbe.org/5m0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m0t RCSB], [https://www.ebi.ac.uk/pdbsum/5m0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m0t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A1L1QK38_ASPJA A0A1L1QK38_ASPJA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Aj_EasH is a non-heme iron- and alpha-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 A resolution) reported here provides insight into the mechanism of this unusual and complex reaction. | |||
Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis.,Jakubczyk D, Caputi L, Stevenson CE, Lawson DM, O'Connor SE Chem Commun (Camb). 2016 Dec 6;52(99):14306-14309. PMID:27885368<ref>PMID:27885368</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5m0t" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aspergillus japonicus]] | |||
[[Category: Large Structures]] | |||
[[Category: Caputi L]] | |||
[[Category: Jakubczyk D]] | |||
[[Category: Lawson DM]] | |||
[[Category: O'Connor SE]] | |||
[[Category: Stevenson CEM]] | |||
Latest revision as of 18:19, 1 November 2023
Alpha-ketoglutarate-dependent non-heme iron oxygenase EasH
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