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[[Image:1piu.gif|left|200px]]


{{Structure
==OXIDIZED RIBONUCLEOTIDE REDUCTASE R2-D84E MUTANT CONTAINING OXO-BRIDGED DIFERRIC CLUSTER==
|PDB= 1piu |SIZE=350|CAPTION= <scene name='initialview01'>1piu</scene>, resolution 2.20&Aring;
<StructureSection load='1piu' size='340' side='right'caption='[[1piu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>
<table><tr><td colspan='2'>[[1piu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIU FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= RIR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1piu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piu OCA], [https://pdbe.org/1piu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1piu RCSB], [https://www.ebi.ac.uk/pdbsum/1piu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1piu ProSAT]</span></td></tr>
|RELATEDENTRY=[[1pim|1PIM]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piu OCA], [http://www.ebi.ac.uk/pdbsum/1piu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1piu RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pi/1piu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1piu ConSurf].
<div style="clear:both"></div>


'''OXIDIZED RIBONUCLEOTIDE REDUCTASE R2-D84E MUTANT CONTAINING OXO-BRIDGED DIFERRIC CLUSTER'''
==See Also==
 
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1PIU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIU OCA].
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Baldwin J]]
[[Category: Baldwin, J.]]
[[Category: Bollinger Jr JM]]
[[Category: Jr., J M.Bollinger.]]
[[Category: Khidekel N]]
[[Category: Khidekel, N.]]
[[Category: Ley BA]]
[[Category: Ley, B A.]]
[[Category: Rosenzweig AC]]
[[Category: Rosenzweig, A C.]]
[[Category: Voegtli WC]]
[[Category: Voegtli, W C.]]
[[Category: four-helix bundle]]
[[Category: oxo-bridged diferric cluster]]
 
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Retrieved from "https://proteopedia.org/1piu"