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==Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0071==
==Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0071==
<StructureSection load='5e93' size='340' side='right' caption='[[5e93]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
<StructureSection load='5e93' size='340' side='right'caption='[[5e93]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5e93]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E93 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5e93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E93 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LL:5-[(E)-3-(FURAN-2-YL)PROP-2-ENYLIDENE]-1,3-DIAZINANE-2,4,6-TRIONE'>5LL</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ea9|5ea9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5LL:5-[(E)-3-(FURAN-2-YL)PROP-2-ENYLIDENE]-1,3-DIAZINANE-2,4,6-TRIONE'>5LL</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e93 OCA], [https://pdbe.org/5e93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e93 RCSB], [https://www.ebi.ac.uk/pdbsum/5e93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e93 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e93 OCA], [http://pdbe.org/5e93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e93 RCSB], [http://www.ebi.ac.uk/pdbsum/5e93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e93 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.  
[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
 
==See Also==
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cheleski, J]]
[[Category: Large Structures]]
[[Category: Harada, S]]
[[Category: Trypanosoma cruzi strain CL Brener]]
[[Category: Inaoka, D K]]
[[Category: Cheleski J]]
[[Category: Kita, K]]
[[Category: Harada S]]
[[Category: Montanari, C A]]
[[Category: Inaoka DK]]
[[Category: Rocha, J R]]
[[Category: Kita K]]
[[Category: Shiba, T]]
[[Category: Montanari CA]]
[[Category: Covalent inhibitor]]
[[Category: Rocha JR]]
[[Category: Dihydroorotate dehydrogenase]]
[[Category: Shiba T]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: T. cruzi]]

Latest revision as of 06:17, 5 July 2023

Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0071

5e93, resolution 1.41Å

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