5tia: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161==
==Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161==
<StructureSection load='5tia' size='340' side='right' caption='[[5tia]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
<StructureSection load='5tia' size='340' side='right'caption='[[5tia]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5tia]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5tia]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TIA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.441&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ti9|5ti9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tia OCA], [https://pdbe.org/5tia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tia RCSB], [https://www.ebi.ac.uk/pdbsum/5tia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tia ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tia OCA], [http://pdbe.org/5tia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tia RCSB], [http://www.ebi.ac.uk/pdbsum/5tia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tia ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN]] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).  
[https://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 5tia" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5tia" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Tryptophan 2,3-dioxygenase]]
[[Category: Homo sapiens]]
[[Category: Forouhar, F]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Forouhar F]]
[[Category: Tong, L]]
[[Category: Karkashon S]]
[[Category: 3-dioxygenase]]
[[Category: Lew S]]
[[Category: Human tryptophan 2]]
[[Category: Lewis-Ballester A]]
[[Category: Nesg]]
[[Category: Seetharaman J]]
[[Category: Oxidoreductase]]
[[Category: Tong L]]
[[Category: Psi-biology]]
[[Category: Yeh SR]]
Retrieved from "https://proteopedia.org/5tia"