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==KALLIKREIN-7 IN COMPLEX WITH COMPOUND1==
==KALLIKREIN-7 IN COMPLEX WITH COMPOUND1==
<StructureSection load='5fah' size='340' side='right' caption='[[5fah]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='5fah' size='340' side='right'caption='[[5fah]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FAH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FAH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [http://pdbe.org/5fah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [http://www.ebi.ac.uk/pdbsum/5fah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [https://pdbe.org/5fah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [https://www.ebi.ac.uk/pdbsum/5fah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.  
[https://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fah" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fah" style="background-color:#fffaf0;"></div>
==See Also==
*[[Kallikrein 3D structures|Kallikrein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Stratum corneum chymotryptic enzyme]]
[[Category: Homo sapiens]]
[[Category: Ostermann, N]]
[[Category: Large Structures]]
[[Category: Zink, F]]
[[Category: Ostermann N]]
[[Category: Hydrolase]]
[[Category: Zink F]]
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