5tr4: Difference between revisions
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==Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243== | |||
<StructureSection load='5tr4' size='340' side='right'caption='[[5tr4]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5tr4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TR4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=61T:[(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl+sulfamate'>61T</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr4 OCA], [https://pdbe.org/5tr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tr4 RCSB], [https://www.ebi.ac.uk/pdbsum/5tr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UBA1_YEAST UBA1_YEAST] Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. | |||
==See Also== | |||
*[[3D structures of Ubiquitin activating enzyme|3D structures of Ubiquitin activating enzyme]] | |||
*[[3D structures of ubiquitin|3D structures of ubiquitin]] | |||
[[Category: | __TOC__ | ||
[[Category: Sintchak | </StructureSection> | ||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Sintchak MD]] | |||
Latest revision as of 13:08, 4 October 2023
Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243
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