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==Crystal structure of the complex MMP-8/BF471 (catechol inhibitor)==
==Crystal structure of the complex MMP-8/BF471 (catechol inhibitor)==
<StructureSection load='5h8x' size='340' side='right' caption='[[5h8x]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='5h8x' size='340' side='right'caption='[[5h8x]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5h8x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H8X FirstGlance]. <br>
<table><tr><td colspan='2'>[[5h8x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H8X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5XT:~{N}-[3,4-BIS(OXIDANYL)PHENYL]-4-PHENYL-BENZENESULFONAMIDE'>5XT</scene>, <scene name='pdbligand=7FY:~{N}-[4,5-BIS(OXIDANYLIDENE)CYCLOHEXEN-1-YL]-4-PHENYL-BENZENESULFONAMIDE'>7FY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XT:~{N}-[3,4-BIS(OXIDANYL)PHENYL]-4-PHENYL-BENZENESULFONAMIDE'>5XT</scene>, <scene name='pdbligand=7FY:~{N}-[4,5-BIS(OXIDANYLIDENE)CYCLOHEXEN-1-YL]-4-PHENYL-BENZENESULFONAMIDE'>7FY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8x OCA], [http://pdbe.org/5h8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h8x RCSB], [http://www.ebi.ac.uk/pdbsum/5h8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h8x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8x OCA], [https://pdbe.org/5h8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h8x RCSB], [https://www.ebi.ac.uk/pdbsum/5h8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h8x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN]] Can degrade fibrillar type I, II, and III collagens.  
[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5h8x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5h8x" style="background-color:#fffaf0;"></div>
==See Also==
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Neutrophil collagenase]]
[[Category: Homo sapiens]]
[[Category: Capelli, D]]
[[Category: Large Structures]]
[[Category: Montanari, R]]
[[Category: Capelli D]]
[[Category: Pochetti, G]]
[[Category: Montanari R]]
[[Category: Tortorella, P]]
[[Category: Pochetti G]]
[[Category: Catechol function]]
[[Category: Tortorella P]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Metalloprotese]]
[[Category: Mmp]]
[[Category: Zinc binding function]]
Retrieved from "https://proteopedia.org/5h8x"