5eww: Difference between revisions
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==Crystal structure of the human BRPF1 bromodomain in complex with SEED21== | ==Crystal structure of the human BRPF1 bromodomain in complex with SEED21== | ||
<StructureSection load='5eww' size='340' side='right' caption='[[5eww]], [[Resolution|resolution]] 1.73Å' scene=''> | <StructureSection load='5eww' size='340' side='right'caption='[[5eww]], [[Resolution|resolution]] 1.73Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5eww]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWW OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5eww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EWW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5SK:~{N}-[(2~{R})-BUTAN-2-YL]-1-METHYL-[1,2,4]TRIAZOLO[4,3-A]QUINOXALIN-4-AMINE'>5SK</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5SK:~{N}-[(2~{R})-BUTAN-2-YL]-1-METHYL-[1,2,4]TRIAZOLO[4,3-A]QUINOXALIN-4-AMINE'>5SK</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eww OCA], [https://pdbe.org/5eww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eww RCSB], [https://www.ebi.ac.uk/pdbsum/5eww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eww ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
==See Also== | |||
*[[Peregrin|Peregrin]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Caflisch A]] | ||
[[Category: | [[Category: Wiedmer L]] | ||
[[Category: | [[Category: Zhu J]] | ||
Latest revision as of 11:34, 10 January 2024
Crystal structure of the human BRPF1 bromodomain in complex with SEED21
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