5mjt: Difference between revisions

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New page: '''Unreleased structure''' The entry 5mjt is ON HOLD Authors: Marca, A., Sandner, A., Heine, A., Klebe, G. Description: Thrombin Mutant A190S in complex with (S)-1-((R)-2-amino-3,3-dip...
 
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'''Unreleased structure'''


The entry 5mjt is ON HOLD
==Thrombin Mutant A190S in complex with (S) -1 - ((R) -2-amino-3,3-diphenylpropanoyl) -N- (3-chlorobenzyl) pyrrolidine-2-carboxamide==
<StructureSection load='5mjt' size='340' side='right'caption='[[5mjt]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mjt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MJT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=23U:BETA-PHENYL-D-PHENYLALANYL-N-(3-CHLOROBENZYL)-L-PROLINAMIDE'>23U</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mjt OCA], [https://pdbe.org/5mjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mjt RCSB], [https://www.ebi.ac.uk/pdbsum/5mjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mjt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HIRV2_HIRME HIRV2_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.


Authors: Marca, A., Sandner, A., Heine, A., Klebe, G.
==See Also==
 
*[[Hirudin 3D structures|Hirudin 3D structures]]
Description: Thrombin Mutant A190S in complex with (S)-1-((R)-2-amino-3,3-diphenylpropanoyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide
*[[Thrombin 3D Structures|Thrombin 3D Structures]]
[[Category: Unreleased Structures]]
__TOC__
[[Category: Sandner, A]]
</StructureSection>
[[Category: Marca, A]]
[[Category: Hirudo medicinalis]]
[[Category: Klebe, G]]
[[Category: Homo sapiens]]
[[Category: Heine, A]]
[[Category: Large Structures]]
[[Category: Heine A]]
[[Category: Klebe G]]
[[Category: Marca A]]
[[Category: Sandner A]]
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