5u2f: Difference between revisions

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'''Unreleased structure'''


The entry 5u2f is ON HOLD
==BRD4 first bromodomain (BD1) in complex with dual PI3 kinase (PI3K) inhibitor SF2558HA==
<StructureSection load='5u2f' size='340' side='right'caption='[[5u2f]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5u2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U2F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.525&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=82Y:N-HYDROXY-4-[5-(MORPHOLIN-4-YL)-7-OXO-7H-THIENO[3,2-B]PYRAN-3-YL]BENZAMIDE'>82Y</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u2f OCA], [https://pdbe.org/5u2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u2f RCSB], [https://www.ebi.ac.uk/pdbsum/5u2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u2f ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Authors: Andrews, F.H., Kutateladze, T.G.
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
Description: BRD4 second bromodomain (BD2) in complex with dual PI3 kinase inhibitor SF2558HA
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Kutateladze, T.G]]
__TOC__
[[Category: Andrews, F.H]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Andrews FH]]
[[Category: Kutateladze TG]]
Retrieved from "https://proteopedia.org/5u2f"