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==CRYSTAL STRUCTURE OF THE KINETOCHORE MIS12 COMPLEX HEAD2 SUBDOMAIN CONTAINING DSN1 AND NSL1 FRAGMENTS==
==CRYSTAL STRUCTURE OF THE KINETOCHORE MIS12 COMPLEX HEAD2 SUBDOMAIN CONTAINING DSN1 AND NSL1 FRAGMENTS==
<StructureSection load='5lsi' size='340' side='right' caption='[[5lsi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5lsi' size='340' side='right'caption='[[5lsi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5lsi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LSI FirstGlance]. <br>
<table><tr><td colspan='2'>[[5lsi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LSI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.002&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsi OCA], [http://pdbe.org/5lsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lsi RCSB], [http://www.ebi.ac.uk/pdbsum/5lsi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsi ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsi OCA], [https://pdbe.org/5lsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lsi RCSB], [https://www.ebi.ac.uk/pdbsum/5lsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DSN1_HUMAN DSN1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:15502821</ref> <ref>PMID:16585270</ref> [[http://www.uniprot.org/uniprot/NSL1_HUMAN NSL1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:16585270</ref> 
[https://www.uniprot.org/uniprot/DSN1_HUMAN DSN1_HUMAN] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:15502821</ref> <ref>PMID:16585270</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Keller, J]]
[[Category: Homo sapiens]]
[[Category: Liu, Y]]
[[Category: Large Structures]]
[[Category: Petrovic, A]]
[[Category: Keller J]]
[[Category: Vetter, I R]]
[[Category: Liu Y]]
[[Category: Alpha-helical]]
[[Category: Petrovic A]]
[[Category: Cell cycle]]
[[Category: Vetter IR]]
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