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==32 kDa Fragment of the Flagellar hook protein FlgE from Caulobacter crescentus==
==32 kDa Fragment of the Flagellar hook protein FlgE from Caulobacter crescentus==
<StructureSection load='5ay6' size='340' side='right' caption='[[5ay6]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='5ay6' size='340' side='right'caption='[[5ay6]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ay6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AY6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ay6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides_CB15 Caulobacter vibrioides CB15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AY6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1io1|1io1]], [[1wlg|1wlg]], [[2d4y|2d4y]], [[2d4x|2d4x]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.839&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ay6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay6 OCA], [http://pdbe.org/5ay6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ay6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ay6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ay6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay6 OCA], [https://pdbe.org/5ay6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ay6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ay6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay6 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/FLGE_CAUVC FLGE_CAUVC]
Across bacteria, the protein that makes the flagellar hook, FlgE, has a high variability in amino acid residue composition and sequence length. We hereby present the structure of two fragments of FlgE protein from Campylobacter jejuni and from Caulobacter crescentus, which were obtained by X-ray crystallography, and a high-resolution model of the hook from Caulobacter. By comparing these new structures of FlgE proteins, we show that bacterial hook can be divided in two distinct parts. The first part comprises domains that are found in all FlgE proteins and that will make the basic structure of the hook that is common to all flagellated bacteria. The second part, hyper-variable both in size and structure, will be bacteria dependent. To have a better understanding of the C. jejuni hook, we show that a special strain of Salmonella enterica, which was designed to encode a gene of flgE that has the extra domains found in FlgE from C. jejuni, is fully motile. It seems that no matter the size of the hook protein, the hook will always have a structure made of 11 protofilaments.
 
Structural insights into bacterial flagellar hooks similarities and specificities.,Yoon YH, Barker CS, Bulieris PV, Matsunami H, Samatey FA Sci Rep. 2016 Oct 19;6:35552. doi: 10.1038/srep35552. PMID:27759043<ref>PMID:27759043</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ay6" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[User:Fadel A. Samatey/FlgE I|User:Fadel A. Samatey/FlgE I]]
*[[Flagellar protein 3D structures|Flagellar protein 3D structures]]
== References ==
*[[The Bacterial Flagellar Hook|The Bacterial Flagellar Hook]]
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Matsunami, H]]
[[Category: Caulobacter vibrioides CB15]]
[[Category: Samatey, F A]]
[[Category: Large Structures]]
[[Category: Yoon, Y H]]
[[Category: Matsunami H]]
[[Category: Flagellum]]
[[Category: Samatey FA]]
[[Category: Hook]]
[[Category: Yoon Y-H]]
[[Category: Motor protein]]
[[Category: Universal joint]]
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