Vinculin: Difference between revisions

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== Relevance ==
== Relevance ==
Loss of VCL could be used as a prognostic factor for colorectal cancer se it promotes metastasis<ref>PMID:25496021</ref>.
Loss of VCL could be used as a prognostic factor for colorectal cancer se it promotes metastasis<ref>PMID:25496021</ref>.
== Disease ==
Mutation in m-VCL can yield cardiomyopathic phenotype<ref>PMID:16236538</ref>.


== Structural highlights ==
== Structural highlights ==
<scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition.
<scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition.
</StructureSection>
 
== 3D Structures of Vinculin ==
== 3D Structures of Vinculin ==
[[Vinculin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Vinculin
**[[1tr2]] – hVCL - human<br />
**[[1qkr]] – hVCL C-terminal<br />
**[[3h2v]] - hVCL C-terminal + raver1 RRM<br />
**[[4pr9]] - hVCL C-terminal + lipid<br />
**[[3h2u]] – hVCL Vd1 + raver1 RRM <br />
**[[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from ''Shigella flexneri''<br />
**[[1ydi]] - hVCL Vd1+hActinin VBS<br />
**[[1t01]] - cVCL Vd1+mTalin VBS – chicken<br />
**[[1syq]], [[1rkc]], [[1rke]] – hVCL Vd1+hTalin VBS<br />
**[[3zdl]] – cVCL Vd1 + amyloid β precursor protein N terminal<br />
*Metavinculin
**[[3myi]] – m-VCL tail domain <br />
**[[3rf3]] - hm-VCL + invasin IPAA<br />
**[[3s90]] - hm-VCL head domain + mTalin-1 peptide<br />
**[[4dj9]] - hm-VCL head domain + hTalin-1 peptide <br />
**[[3tj5]] - hm-VCL head domain + Sca-family protein peptide<br />
**[[3tj6]] - hm-VCL head domain + protein Ps 120 peptide<br />
**[[4ehp]] - hm-VCL head domain + catenin α-1 residues 277-382<br />
**[[3vf0]] – hm-VCL residues 856-1134 + ribonucleoprotein PTB-binding<br />
**[[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal <br />
**[[1xwj]] - cm-VCL Vd1+cTalin VBS3<br />
**[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cm-VCL Vd1+cTalin rod<br />
**[[1st6]] – cm-VCL<br />
**[[4e17]], [[4e18]] - cm-VCL Vd1 + catenin α-1 VCL-binding domain
}}
==References==
==References==
<references />
<references />
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]


*Created with the participation of [[User:Susan Craig|Susan Craig]].
*Created with the participation of [[User:Susan Craig|Susan Craig]].
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